The incidence of tissue dysfunction, diseases and many types of cancer exponentially increases above the age of 45, showing a growing number of mutant stem or progenitor clones in the hematopoietic system, and the intestinal epithelium. New research results indicate that an increasing number of mutations in tissue stem cells are the main reason for carcinogenesis in age, starting years before the disease occurs.
However, the mechanisms that initiate stem cell mutations and lead to their clonal dominance are poorly understood. Researchers from age and cancer research institutes in Jena/Germany (Fritz Lipmann Institute (FLI)), Glasgow/UK (Beatson Institute for Cancer Research) and Novato/USA (Buck Institute for Research on Aging) now compiled and presented existing research results in order to show new approaches for the explanation of this dominance.
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