Can umbilical stem cells treat rheumatoid arthritis?

rheumatoid_arthritis_stem_cells

Do you know someone who is pregnant right now? Do you know anyone who has rheumatoid arthritis? I do. Actually, in my case, they’re the same person.

Beccy and I grew up together. We were in the same class until we were 16 years old. We were both in the choir, though she was the one with the talent and played the lead in our school plays.

 

Arthritis hurts some people their whole lifetime

Beccy was also born with rheumatoid arthritis. I don’t think I’ve ever heard her complain about it, but it’s always there, not far beneath the surface. When she politely declines certain activities we don’t always realise soon enough that it’s because it will hurt the joints in her hands, where she suffers most. And there’s always been an unspoken understanding that there are certain things she might not do. Like have children.

Beccy is now an auntie several times over and has taken boyfriend’s children under her wing in the past. Many of our friends’ children are at secondary school themselves now so I suppose we assumed pregnancy was something Beccy would never do.

rheumatoid arthritis infographic

 

Rheumatoid arthritis affects many young women like Beccy

Can umbilical stem cells cure rheumatoid arthritis?

Maybe. Against the odds, Beccy is expecting her first child very soon. Of course, we’re worried about how her body will cope with this challenge to any woman’s strength and resilience. But so far, she’s feeling strong and looking as well and happy as we’ve ever seen her. It’s fascinating to think that the very thing that nearly prevented Beccy from being a mum could be cured by the cells growing alongside her baby.

The umbilical cord contains two types of stem cells that Biovault Family collect, process and release for treatment. The first, Haematopoietic Stem Cells (HSCs) are found in the blood that is left in the umbilical cord and placenta after the baby is born. Cord blood HSCs have been used since 1988 to treat blood cancers and other life-threatening conditions affecting our blood and immune systems.

Discover the reasons doctors are choosing cord blood stem cells over bone marrow and peripheral blood for cancer treatments.

The second type of stem cell is found in the umbilical cord tissue itself. Mesenchymal stem cells (MSCs) are the parent cells of all of our tissue cells, such as bone, muscle and tendon. These cells could end the pain of rheumatoid arthritis for people like Beccy.

 

What causes rheumatoid arthritis, and how can stem cells help?

In rheumatoid arthritis (RA), the immune system mistakenly attacks the tissue that lines the joints, which can cause pain, inflammation, swelling, and stiffness.

This inflammation can extend to the cartilage that covers the ends of joints and cause irreversible damage and loss of function. It can also damage other tissues, including the lungs, heart, kidney, skin, and eyes.

MSCs can develop into cartilage and bone. Synovial MSC therapy involves injecting these cells directly into the tissues surrounding the affected joints.

 

Is there any evidence that umbilical stem cells can treat rheumatoid arthritis?

Yes. One 2013 study investigated the efficacy of MSC therapy for people with rheumatoid arthritis (RA). All 172 participants continued to take their regular RA medication during the course of the study. A subset of the participants also received two MSC treatments via intravenous injection, while another subset received placebo injections (the controls).

Compared with the controls, those who received the MSC treatment showed a significant remission of the condition. The team measured the extent of remission using the improvement criteria of the American College of Rheumatology, the 28-joint disease activity score, and the Health Assessment Questionnaire.

Improvements also correlated with increased levels of regulatory T cells (RTCs) in the blood. RTCs stop the immune system from attacking the body’s own cells. As such, they play a vital role in controlling inflammation.

The treatment induced a significant remission of disease according to the American College of Rheumatology improvement criteria, the 28-joint disease activity score, and the Health Assessment Questionnaire. 

Stem Cells and DevelopmentVol. 22, No. 24

Research shows that MSCs are able to suppress the immune system and reduce the body’s inflammatory response. This makes MSC therapy a promising treatment option for autoimmune conditions such as RA.

 

How can Biovault Family help pregnant women to treat rheumatoid arthritis and other conditions?

When you have a baby, unless you organise for your cord blood and tissue to be collected, it will be thrown away. The stem cells in the placenta and umbilical cord that could have saved the life of someone with cancer or enhanced the life of someone with arthritis are incinerated.

By storing your cord blood and tissue, you protect your family against illness today and tomorrow. Stem cells can be stored and used for treatment for at least 25 years – probably far longer, this is simply the longest cells have been stored for so far.

Biovault is not only a cord blood bank. We’re a human tissue bank, established in 2003. Our cutting-edge laboratory and ethical practice are considered as the industry gold standard, which is why our facilities and team are trusted by the NHS and private clinics.

We were one of the first human tissue banks to see the potential of umbilical cord MSCs and to offer cord tissue storage to families.

 

How does cord blood and tissue storage work?

Our long term partnership with South West Peninsula Transplant Service (NHS) for peripheral blood and bone marrow stem cell transplants began in 2006. We now work on a daily basis with NHS transplant nurses, releasing stem cells and tissues that save and enhance lives. We’re proud to say we do this well. Every one of the samples released by Biovault has successfully engrafted, our highest measure of achievement.

take 15 minutes to organise umbilical stem cell storage now and enjoy peace of mind forever

Sources

https://www.medicalnewstoday.com/articles/325583.php

https://www.liebertpub.com/doi/abs/10.1089/scd.2013.0023

https://www.ncbi.nlm.nih.gov/pubmed/27941390

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